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secobarbital will lower the level or effect of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
secobarbital will reduce the extent or effect of ethotoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Check.
Griseofulvin—Phenobarbital appears to interfere with the absorption of orally administered griseofulvin, thus reducing its blood level.
Minor analgesia is conferred by barbiturates; their use within the existence of ache may possibly result in excitation.
When support-in-dying was 1st passed secondskin in Oregon in 1997, clients got secobarbital, sold under the brand name Seconal. It induces deep sleep, then a coma that is definitely so deep the brain no longer drives respiration.
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secobarbital, calcium/magnesium/potassium/sodium oxybates. Possibly increases effects on the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated due to additive CNS despair.
secobarbital will lower the level or effect of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
secobarbital will decrease the extent or effect of lurasidone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
secobarbital will lower the level or effect of nevirapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Nonteratogenic Effects. Studies of infants struggling from long-term barbiturate exposure in utero involved the acute withdrawal syndrome of seizures and hyperirritability from birth to some delayed onset of as many as 14 days (see Drug Abuse and Dependence).
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